To clarify the relationship between tobacco use and risk of colorectal cancer, we evaluated a cohort of 248,046 American veterans followed prospectively for 26 years.
In comparison with veterans who had never used tobacco, the risk of death was significantly increased for colon cancer and rectal cancer among current and former cigarette smokers and among pipe or cigar smokers, controlling for social class and occupational physical activity.
Rectal-cancer risk was also significantly elevated among users of chewing tobacco or snuff.
For both sites, risk increased significantly with pack-years, earlier age at first use, and number of cigarettes.
These results reinforce 2 recent reports of the association of cigarette smoking and colorectal cancer in men and women.
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Facteur risque, Epidémiologie, Tabagisme, Ancien combattant, Etats Unis, Amérique du Nord, Amérique, Etude longitudinale, Homme, Côlon pathologie, Rectum pathologie, Intestin pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Risk factor, Epidemiology, Tobacco smoking, Veteran, United States, North America, America, Follow up study, Human, Colonic disease, Rectal disease, Intestinal disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0147012
Code Inist : 002B13B01. Création : 09/06/1995.