The involvement of immunological reactivity to ranitidine base (R-b) and ranitidine hydrochloride (R-HCl) in the development of occupationally related symptomatology was analyzed in 40 subjects employed in a pharmaceutical plant producing ranitidine and in 33 nonexposed controls, using a specific dose-response lymphocyte proliferative test (lymphocyte transformation test : LTT).
Of the 40 workers, 11 (28%) gave positive reactions to LTT : 3/11 to R-b, 4/11 to R-HCl, and 4/11 to both compounds.
None of the controls gave positive reactions.
Cutaneous, oculonasal, or respiratory work-related symptoms were cited by 23 of the 40 (58%) subjects ; ten of these 23 subjects (43%) were LTT positive.
One asymptomatic case was LTT positive.
The present results indicate that specific immune reactivity to ranitidine, analyzed by LTT, is associated with the presence of occupational symptomatology ; R-HCl and R-b seem to share some antigenic determinants, because of the partial cross-reactivity shown by the examined compounds.
Nonimmunological, probably irritative, mechanisms are also present in some of the symptomatic subjects.
Mots-clés Pascal : Ranitidine, Antiulcéreux, Antihistaminique, Récepteur histaminergique H2, Industrie pharmaceutique, Exposition professionnelle, Toxicité, Homme, Sensibilisation, Test transformation lymphoblastique, Réponse immune, Immunopathologie, Médecine travail
Mots-clés Pascal anglais : Antiulcer agent, Antihistaminic, H2 receptor, Pharmaceutical industry, Occupational exposure, Toxicity, Human, Sensitization, Lymphocyte transformation test, Immune response, Immunopathology, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0143758
Code Inist : 002B02U10. Création : 09/06/1995.