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  1. Assessment of long-term styrene exposure : a comparative study of a logbook method and biological monitoring.

    Article - En anglais

    In a recent joint European research project a logbook method for assessment of long-term styrene exposure was applied in two Danish factories manufacturing glass fibre-reinforced polyester.

    The method was based on work process identification, assignment of work process concentrations and logbook keeping.

    Measures of exposure calculated by this method were compared with results from simultaneous measurements of styrene in blood and the metabolites mandelic acid and phenylglyoxylic acid in urine.

    Correlations were comparable with those obtained by use of personal samplers as published in the literature.

    Styrene in blood only correlated with logbook concentrations at the time of sampling.

    Exposures were moderate to low.

    Mean personal 8-h time-weighted average concentration (8hTWAC) was 76 mg/m3 styrene (SD 54 mg/m3, range 2-230 mg/m3).

    The Danish 8hTWAC threshold limit value for styrene in air, 105 mg/m3 (25 ppm), was exceeded on 17% of personal days.

    The summed urinary metabolites, mandelic acid and phenylglyoxylic acid, had a mean personal value of 138 mg/g creatinine (SD 84 mg/g creatinine) on the day of sampling.

    Blood styrene mean value was 129 mug/1 (SD 74 mug/l, range 66-358 mug/l).

    It is concluded that the logbook method offers a technique for testing whether measurements are performed on representative days and may be recommended as a tool supplementary to biological monitoring in the assessment of long-term exposure.

    Mots-clés Pascal : Styrène, Exposition professionnelle, Homme, Surveillance biologique, Méthode étude, Relation dose métabolisme, Urine, Fibre verre, Industrie, Long terme, Médecine travail, Danemark, Europe, Etude comparative, Solvant organique

    Mots-clés Pascal anglais : Styrene, Occupational exposure, Human, Biological monitoring, Investigation method, Dose metabolism relationship, Urine, Glass fiber, Industry, Long term, Occupational medicine, Denmark, Europe, Comparative study, Organic solvent

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0143757

    Code Inist : 002B03L04. Création : 09/06/1995.