Objectives-To investigate the incidence of allergy to laboratory animals (ALA) during the first two years of employment, and to study the effect on ALA of atopy and sensitisation.
Methods follow up prospective study of ALA at the Zeneca (formerly ICI) Research Laboratories.
The incidence of the disease during the first year of employment has remained at about 10% since the mid-1980s.
This compares with an incidence of 37% in the early 1980s.
The reduction in incidence and its maintenance at a lower level is thought to be due to the introduction and management of improved engineering controls, working practices, and educational programmes designed to reduce exposure to allergens from laboratory animals.
The underlying incidence of immunological sensitisation to animals (the presence of immunoglobulin E (IgE) antibodies to animal allergens) is much higher (40% after one and 53% after two years of exposure).
Both atopic diathesis and presensitisation to laboratory animals increased the likelihood that a person would develop ALA.
Conclusion-Neither factor predicted the disease accurately so their use should be restricted to the identification of people who may be more susceptible to the development of ALA (and thus who may need to pay particular attention to the use of personal protective equipment) rather than to their exclusion.
Mots-clés Pascal : Allergie, Exposition professionnelle, Animal laboratoire, Homme, Personnel laboratoire, Atopie, Sensibilisation, Médecine travail, Immunopathologie
Mots-clés Pascal anglais : Allergy, Occupational exposure, Laboratory animal, Human, Laboratory staff, Atopy, Sensitization, Occupational medicine, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0143602
Code Inist : 002B06C05. Création : 09/06/1995.