Induction of P-450 in workers exposed to dioxin.
Objectives-To examine the effects of occupational exposure to substances contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cytochrome P-4501A2 activity in a cross sectional medical survey.
Methods-The exposed workers had been employed at two chemical plants 715 years earlier in the manufacture of 2,4,5-trichlorophenol and its derivatives.
The control group consisted of people with no occupational exposure to phenoxy herbicides and who lived within the communities of the exposed workers.
A total of 58 workers and 125 unexposed controls participated in the analysis.
Compared with the control group in multivariate logistic regression, raised non-significant associations were found for three of four categories of TCDD in exposed workers (TCDD<20 pg/g, odds ratio (OR) 1.7,95% confidence interval (95% CI) 0.6 to 5.0, TCDD20.66, OR 0.3,95% CI 0.0 to 1.7 ; TCDD 67.147, OR 2.3,95% CI 0.6 to 8.8 ; TCDD =148, OR 3.1,95% CI 0.8 to 12.5).
We found a strongly significant association of CMR and urinary cotinine, a measure of smoking, and urinary free ethanol.
We found weak non-significant associations between P-4501A2 activity and increased serum TCDD among workers.
Conclusions-The absence of an association between serum TCDD and cytochrome P-4501A2 may be due to the size of the study, insensitivity of the CMR to assess cytochrome P-4501A2 activity, or inadequate levels of exposure, although these were among the highest in human groups tested.
Mots-clés Pascal : Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Exposition professionnelle, Toxicité, Cytochrome P450, Homme, Industrie chimique, Relation concentration activité, Epidémiologie, Médecine travail, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Occupational exposure, Toxicity, Cytochrome P450, Human, Chemical industry, Activity concentration relation, Epidemiology, Occupational medicine, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0143594
Code Inist : 002B03L06. Création : 09/06/1995.