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  1. Bronchial dysplasia induced by radiation in miners exposed to 222Rn progeny.

    Article - En anglais

    Objectivess-To investigate whether sputum cytology can be used to monitor epithelial cell changes in groups at high risk of lung cancer from exposure to radiation.

    Methods-Dysplasia of bronchial cells was investigated by means of sputum cytology in a group of 434 underground miners. 100 of them were not exposed, and 334 were exposed to 222Rn progeny at cumulative exposures<450 working level months.

    Results

    The frequency of dysplasia in the exposed group was significantly higher the that in the not exposed group (P<0.0001), and an exposure-response relation was found.

    This relation was different for smokers and non-smokers.

    Conclusions-Possibly the frequencies of dysplasia could be used to assess past exposures of groups of miners.

    This approach could be applied to cases where data on radiation monitoring are not available or are very scarce.

    Mots-clés Pascal : Dysplasie, Bronchopulmonaire, Tumeur maligne, Exposition professionnelle, Toxicité, Homme, Radiocontamination, Radon, Médecine travail, Mine, Bulgarie, Europe, Epidémiologie, Appareil respiratoire pathologie, Radon 222

    Mots-clés Pascal anglais : Dysplasia, Bronchopulmonary, Malignant tumor, Occupational exposure, Toxicity, Human, Radioactive contamination, Radon, Occupational medicine, Mine, Bulgaria, Europe, Epidemiology, Respiratory disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0143593

    Code Inist : 002B11A. Création : 09/06/1995.