Objectivess-To investigate whether sputum cytology can be used to monitor epithelial cell changes in groups at high risk of lung cancer from exposure to radiation.
Methods-Dysplasia of bronchial cells was investigated by means of sputum cytology in a group of 434 underground miners. 100 of them were not exposed, and 334 were exposed to 222Rn progeny at cumulative exposures<450 working level months.
The frequency of dysplasia in the exposed group was significantly higher the that in the not exposed group (P<0.0001), and an exposure-response relation was found.
This relation was different for smokers and non-smokers.
Conclusions-Possibly the frequencies of dysplasia could be used to assess past exposures of groups of miners.
This approach could be applied to cases where data on radiation monitoring are not available or are very scarce.
Mots-clés Pascal : Dysplasie, Bronchopulmonaire, Tumeur maligne, Exposition professionnelle, Toxicité, Homme, Radiocontamination, Radon, Médecine travail, Mine, Bulgarie, Europe, Epidémiologie, Appareil respiratoire pathologie, Radon 222
Mots-clés Pascal anglais : Dysplasia, Bronchopulmonary, Malignant tumor, Occupational exposure, Toxicity, Human, Radioactive contamination, Radon, Occupational medicine, Mine, Bulgaria, Europe, Epidemiology, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0143593
Code Inist : 002B11A. Création : 09/06/1995.