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  1. Cocaine abuse and dependence.

    Article - En anglais

    Western countries experienced a widespread cocaine epidemic during the 1980s, and the number of frequent users has not declined in this decade.

    A key factor in the development of this epidemic has been the introduction of « crack, » an affordable form of cocaine that appears to be more addicting than the powder.

    Epidemiologic studies indicate a high incidence of polysubstance abuse among cocaine abusers and probable gender differences in patterns of abuse and response to treatment.

    An abstinence syndrome has been documented in outpatients after the acute cessation of cocaine.

    This pathway may also be part of the neuronal substrates that mediate the reinforcing properties of other classes of abused drugs and, perhaps, motivated behavior in general.

    Because of this potent reinforcing nature of cocaine in humans, the problem of designing effective therapy for its addiction has not been simply solved.

    Clinical treatments, guided by animal studies and designed for specific attack of symptoms of the abstinence syndrome, craving and anhedonia, have been tested.

    To date, only a few agents have proved effective in controlled trials and these have limitations of side effects or delayed onset of action.

    Agents that interact with specific subcomponents of the dopamine system or its connections offer promise for the development of successful agents to treat cocaine abuse and craving in humans.

    Mots-clés Pascal : Alcaloïde, Psychotrope, Traitement, Chimiothérapie, Animal, Homme, Article synthèse, Cocaïne, Substance toxicomanogène, Toxicomanie, Dépendance, Epidémiologie

    Mots-clés Pascal anglais : Alkaloid, Psychotropic, Treatment, Chemotherapy, Animal, Human, Review, Cocaine, Drug of abuse, Drug addiction, Dependence, Epidemiology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0140852

    Code Inist : 002B03D. Création : 09/06/1995.