Following the identification of an index case of occupational asthma, we assessed the respiratory morbidity in 12 workers exposed to aliphatic polyamines in a chemical factory and in 60 unexposed workers in three other workplaces.
Many amine workers reported symptoms of chronic cough (7/12), chronic phlegm (9/12), wheezing (4/12) and exertional breathlessness (3/12).
These were significantly more frequent in exposed than in unexposed workers (P<0.01).
They also had significantly greater diurnal variation in peak expiratory flow rates (DV-PEFR) than the unexposed workers (P<0.01).
All four amine workers with wheezing reported onset of symptoms after employment at the factory, and all had DV-PEFR greater than 15%, compared to only one control worker (P<0.01).
A second case of occupational asthma was confirmed by bronchial challenge test.
The study indicated a very high risk of asthma and chronic airways disease and a need for stringent measures to protect the health of industrial workers exposed to aliphatic amines in Singapore.
Mots-clés Pascal : Asthme, Exposition professionnelle, Homme, Polyamine, Composé aliphatique, Industrie chimique, Singapour, Asie, Médecine travail, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Allergie, Immunopathologie
Mots-clés Pascal anglais : Asthma, Occupational exposure, Human, Polyamine, Aliphatic compound, Chemical industry, Singapore, Asia, Occupational medicine, Respiratory disease, Obstructive pulmonary disease, Allergy, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0139980
Code Inist : 002B06C02. Création : 09/06/1995.