Multiple risk factors associated with arsenic-induced skin cancer : effects of chronic liver disease and malnutritional status.
In order to evaluate the prevalence and multiple risk factors of arsenic-induced skin cancer among residents in Taiwanese villages in which chronic arseniasis is hyperendemic, a total of 1571 subjects aged 30 or more years were recruited between September 1988 and March 1989.
All of them were interviewed personally by a public health nurse using a structured questionnaire, and 1081 interviewed study subjects, including 468 men and 613 women, participated in physical examination, giving a participation rate of 68.8%. The overall prevalence of skin cancer was as high as 6.1%, showing an increase with age in both men and women.
There was a significant dose-response relation between skin cancer prevalence and chronic arsenic exposure as indexed by duration of residence in the endemic area, duration of consumption of high-arsenic artesian well water, average arsenic exposure in parts per million (p.p.m.) and cumulative arsenic exposure in p.p.m. - years.
Chronic carriers of hepatitis B surface antigen with liver dysfunction had an increased prevalence of skin cancer.
Undernourishment, indexed by a high consumption of dried sweet potato as a staple food, was also significantly associated with an increased prevalence of arsenic-induced skin cancer.
All these risk factors remained statistically significant in the multiple logistic regression analysis.
Mots-clés Pascal : Tumeur maligne, Peau, Arsenic, Puits artésien, Toxicité, Facteur risque, Hépatite virale B, Virose, Infection, Chronique, Malnutrition, Epidémiologie, Taiwan, Asie, Homme, Peau pathologie, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Malignant tumor, Skin, Arsenic, Artesian wells, Toxicity, Risk factor, Viral hepatitis B, Viral disease, Infection, Chronic, Malnutrition, Epidemiology, Taiwan, Asia, Human, Skin disease, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0139875
Code Inist : 002B08A. Création : 09/06/1995.