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  1. Determination of PCB metabolic, excretion, and accumulation rates for use as indicators of biological response and relative risk.

    Article - En anglais

    New and old kinetic and chromatographic data were used to calculate, for 146 PCB congeners, the relative rates of metabolism by both P4501A-and P4502B-like cytochromes and the relative human accumulations after 70yr dosing [RHA (70) values] in both normal and chloracnegenic persons.

    These results permitted establishment of structure-activity relationships, detection of dechlorination as a minor metabolic pathway, characterization of inter-species differences in metabolic response (e.g., P4501A induction), and rationalization of inter-Aroclor differences in chronic toxicity.

    They also indicated that for environmental PCB mixtures the now readily calculable RHA (70) values should provide an improved measure of relative chronic health risk, and one that should be particularly useful in the evaluation of bioremediation processes.

    Mots-clés Pascal : Biphényle(polychloro), Analyse quantitative, Matériel biologique, Homme, Exposition professionnelle, Animal, Comparaison interspécifique, Toxicocinétique, Métabolisme, Accumulation biologique, Polluant, Environnement, Relation structure activité, Indicateur biologique, Risque, Article synthèse, Toxicité, Cytochrome P450, Evaluation

    Mots-clés Pascal anglais : Polychlorobiphenyl, Quantitative analysis, Biological material, Human, Occupational exposure, Animal, Interspecific comparison, Toxicokinetics, Metabolism, Biological accumulation, Pollutant, Environment, Structure activity relation, Biological indicator, Risk, Review, Toxicity, Cytochrome P450, Evaluation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0138780

    Code Inist : 002B03M01. Création : 09/06/1995.