This is an update of an earlier study on the relation between exposure to arsenic in air and deaths from respiratory cancer.
The purpose was to verify earlier findings of a supralinear dose response relation and to examine relations with other cancers, particularly those reported in studies on drinking water.
Methods-An earlier study of 2802 men who worked at a copper smelter for a gear or more during the period 1940-64 and who were followed up for deaths during the period 1941-76 was updated until 1986.
Estimates of exposure for the period 1977-1984 were added.
Results and conclusion-The additional follow up confirms the earlier finding that at low doses the increments in death rates for respiratory cancer for a given increment in dose are greater than at high doses.
The additional follow up also shows significant increases in cancer of the large intestine and bone, and SMRs>150 for cancer of the buccal cavity and pharynx, rectal cancer, and kidney cancer.
There was a positive relation between exposure to arsenic in air and kidney and bone cancer, but none for the other cancers, except respiratory.
Mots-clés Pascal : Arsenic, Fonderie, Cuivre, Exposition professionnelle, Tumeur maligne, Bronchopulmonaire, Relation dose réponse, Carcinogène, Homme, Mortalité, Médecine travail, Toxicité, Poumon pathologie, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Arsenic, Foundry, Copper, Occupational exposure, Malignant tumor, Bronchopulmonary, Dose activity relation, Carcinogen, Human, Mortality, Occupational medicine, Toxicity, Lung disease, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0118802
Code Inist : 002B03L05. Création : 09/06/1995.