Epstein-Barr virus infection, salted fish and nasopharyngeal carcinoma : a case-control study in Southern China.
Two hundred and five histologically confirmed cases of nasopharyngeal carcinoma (NPC) in southern China, and an equal number of matched controls, were investigated for their dietary habits, occupational exposure, use of tobacco and alcohol, history of relatives with NPC, and IgA against Epstein-Barr virus (EBV) capsid antigen (IgA/VCA).
Positive IgA/VCA and intake of salted fish were associated with a strong excess risk of NPC.
The association persisted after adjustment for other factors.
The combination of salted fish and EBV was strongly associated with NPC, and more so than EBV or salted fish per se.
Multivariate analyses showed that IgA/VCA was the most important predictor of NPC, and salted fish the second most important.
Mots-clés Pascal : Epithélioma, Nasopharynx, Epidémiologie, Facteur risque, Virose, Infection, Virus Epstein Barr, Gammaherpesvirinae, Herpesviridae, Virus, Coutume alimentaire, Poisson salé, Chine, Asie, Sud, Homme, Tumeur maligne, Pharynx pathologie, Nez pathologie, ORL pathologie
Mots-clés Pascal anglais : Carcinoma, Nasopharynx, Epidemiology, Risk factor, Viral disease, Infection, Epstein Barr virus, Gammaherpesvirinae, Herpesviridae, Virus, Food habit, Salted fish, China, Asia, South, Human, Malignant tumor, Pharynx disease, Nose disease, ENT disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0116412
Code Inist : 002B10B01. Création : 09/06/1995.