Data from a large population based, case-control study were analyzed to determine whether women giving birth to children with major birth defects have different subsequent pregnancy patterns than those giving birth to live-born babies without defects.
Mothers of 4918 infants with major birth defects born from 1968 through 1980 in metropolitan Atlanta were compared with mothers of 3029 control infants, frequency-matched on birth year, birth hospital, and race.
The pregnancy rate in the first 3 years after the index birth was higher among case mothers (36%) than among control mothers (30%, P<. 0001).
This excess was seen for mothers of stillborn case infants (64%) and mothers of case infants who died in infancy (58%), but not for mothers of case infants who survived the first year of life (31%). Pregnancy rates varied by birth defect type.
Maternal and infant factors varied among case and control subjects and influenced subsequent pregnancy rates.
The reproductive behavior observed in this study supports the theory that mothers of nonsurviving children with birth defects compensate by acting to « replace » the lost child.
Reproductive behavior was also strongly associated with having completed a previous pregnancy and by the type of birth defect.
Mots-clés Pascal : Géorgie, Maladie congénitale, Nouveau né, Mère, Démographie, Epidémiologie, Gestation, Incidence, Etats Unis, Amérique du Nord, Amérique, Homme, Etude statistique
Mots-clés Pascal anglais : Georgia, Congenital disease, Newborn, Mother, Demography, Epidemiology, Pregnancy, Incidence, United States, North America, America, Human, Statistical study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0101869
Code Inist : 002B30A01A1. Création : 09/06/1995.