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  1. Development of a whole blood assay to measure T cell responses to leprosy : a new tool for immuno-epidemiological field studies of leprosy immunity.

    Article - En anglais

    A whole blood assay is described to measure T cell mediated immune responses to leprosy and provide an alternative to the conventional lymphocyte transformation test.

    Optimal conditions were defined for the whole blood assay, and interferon-gamma measurement was found to be a more sensitive way of measuring responses than tritiated thymidine incorporation.

    The assay was shown to be useful for investigating responses to a range of leprosy antigens.

    A whole blood assay has the advantages of being quick, simple and requiring only a small volume of blood, making it more appropriate as an immuno-epidemiological field test in leprosy endemic areas.

    Mots-clés Pascal : Lymphocyte T, Interféron gamma, Réponse immune, Antigène, Epidémiologie, Immunogénicité, Sang, Lèpre, Mycobactériose, Bactériose, Infection, Peau pathologie

    Mots-clés Pascal anglais : T-Lymphocyte, Gamma interferon, Immune response, Antigen, Epidemiology, Immunogenicity, Blood, Leprosy, Mycobacterial infection, Bacteriosis, Infection, Skin disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0087710

    Code Inist : 002B05B02L1. Création : 09/06/1995.