Serum alanine aminotransferase measurement as a guide to selective testing for hepatitis C during medical checkup.
The efficiency of elevated serum alanine aminotransferase values for selecting subjects to be tested for hepatitis B or C infections in a large French population undergoing a medical checkup was investigated.
For 5 consecutive weeks, serum alanine aminotransferase values were controlled in 9044 subjects ; 308 subjects (202 males) were selected with alanine aminotransferase levels 1.2-fold above the normal value (58 iu/l for men, 34 iu/l for women).
For each selected case, an age-and sex-cross-matched control was included.
Of the 308 subjects with elevated alanine aminotransferase values, one was HBsAg positive and 15 (seven males) were anti-HCV positive.
All anti-HCV sera tested by enzyme immunoassay were also positive by three immunoblots and 11/15 (73%) were HCV-RNA positive by reverse transcription-polymerase chain reaction.
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Alanine transaminase, Transaminases, Transferases, Enzyme, Diagnostic, Sérum, Analyse quantitative, Homme, Epidémiologie, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Alanine transaminase, Transaminases, Transferases, Enzyme, Diagnosis, Serum, Quantitative analysis, Human, Epidemiology, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0085891
Code Inist : 002B05C02G. Création : 09/06/1995.