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  1. Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.

    Article - En anglais

    Background 

    Gastric cancer remains a major cause of mortality and will remain so for the lifetime of current clinicians.

    Many cancers are diagnosed at a stage when current therapy cannot provide the hope of cure.

    A method for early detection of gastric cancer which can be widely applied is needed.

    The serum levels of pepsinogen A and gastrin-17 have been shown to vary in the presence of pathologic conditions of the gastric mucosa and may provide such a tool.

    Methods 

    Serum samples were obtained from 432 patients undergoing endoscopy for undiagnosed dyspepsia.

    The levels of pepsinogen I and gastrin-17 were estimated by radioimmunoassay and compared with the final diagnosis.

    Mots-clés Pascal : Tumeur maligne, Estomac, Pepsinogène, Gastrine, Diagnostic, Marqueur biologique, Dépistage, Homme, Appareil digestif pathologie, Estomac pathologie, Hormone gastrointestinale, Hormone peptide

    Mots-clés Pascal anglais : Malignant tumor, Stomach, Pepsinogen, Gastrin, Diagnosis, Biological marker, Medical screening, Human, Digestive diseases, Gastric disease, Gastrointestinal hormone, Peptide hormone

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0072546

    Code Inist : 002B13B01. Création : 09/06/1995.