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  1. Genetic epidemiology of early onset breast cancer.

    Article - En anglais

    Risks for breast cancer when there is a family history of the disease are usually calculated using data from segregation analyses which favour a single dominant gene with high penetrance.

    There are, however, at least three loci known to be associated with familial breast cancer (p53, BRCA1, and an as yet unpublished locus) and the frequencies and penetrances of these genes are not likely to be the same.

    We have attempted to address the problem of which genetic parameters should be used to calculate risks for different patterns of familial breast cancer.

    Mots-clés Pascal : Tumeur maligne, Glande mammaire, Homme, Génétique épidémiologique, Analyse ségrégation, Epidémiologie, Glande mammaire pathologie

    Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Human, Epidemiologic genetics, Segregation analysis, Epidemiology, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0063758

    Code Inist : 002B20E02. Création : 09/06/1995.