Etiological subgroups in non-syndromic isolated cleft palate. A genetic-epidemiological study of 52 Danish birth cohorts.
Isolated cleft palate (CP) is considered to be a heterogeneous trait with an important genetic contribution to the etiology.
Multifactorial-threshold models of non-syndromic CP inheritance assume a female predominance.
The present study of 52 Danish birth cohorts, using several ascertainment sources, identified 2301 CP cases.
It was found that, although females tended to be more severely affected than males, the overall sex ratio was close to one.
For the latter half of the study period (1962-87), which probably had the best ascertainment, the sex ratio for non-syndromic CP was 0.95 (95% C.I. 0.85-1.07).
Marked difference in sex ratios for non-syndromic overt CP including the hard palate (CPH) and nonsyndromic overt CP of the soft palate only (CPS) (0.69 vs 1.00, p<1.00, p<0.05) suggested that these two conditions may by etiologically distincts, a hypothesis which is embryologically plausible.
Mots-clés Pascal : Fissure congénitale, Palais, Homme, Etiologie, Sex ratio, Analyse ségrégation, Danemark, Europe, Epidémiologie, Stomatologie, Cavité buccale pathologie, Maladie congénitale, Malformation
Mots-clés Pascal anglais : Cleft, Palate, Human, Etiology, Sex ratio, Segregation analysis, Denmark, Europe, Epidemiology, Stomatology, Oral cavity disease, Congenital disease, Malformation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0057486
Code Inist : 002B10C02. Création : 09/06/1995.