Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride (HHPA) was studied in exposed workers.
The relation between exposure to HHPA and the levels of specific immunoglobin E [ (radioallergosorbent test (RAST) ] and immunoglobin G (enzyme-linked immunosorbent assay) antibodies was investigated in a cross-sectional study on 95 workers from two plants using epoxy resin with HHPA as a hardener, the mean time of exposure was 7 (range 0.1-25) years.
The specific immunoglobin E and immunoglobin G was significantly increased in exposed workers when they were compared with unexposed workers or external referents.
Mots-clés Pascal : Epoxyde résine, Anhydride organique, Exposition professionnelle, Relation dose réponse, Homme, IgE, IgG, Sensibilisation, Médecine travail, Isobenzofurane-1,3-dione
Mots-clés Pascal anglais : Epoxy resin, Organic anhydride, Occupational exposure, Dose activity relation, Human, IgE, IgG, Sensitization, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0053405
Code Inist : 002B03L06. Création : 09/06/1995.