The study evaluated the possibility of a direct association between silica dust exposure and lung cancer.
Mortality and morbidity among 1026 granite workers was followed in 1940-1989.
Regional census data for 1970-1985 and lung cancer incidence data were also linked.
The cytotoxicity of different granite fractions and their capacity to induce reactive oxygen species (ROS) in human leukocytes was studied in vitro.
Excess lung cancer mortality was found during several follow-up periods.
The rate ratios were 1.6-3.8 for different latency periods.
Lung cancer risk increased with the length of exposure and latency.
Lung cancer morbidity in 1953-1987 showed an excess for the red and grey granite areas, the rate ratio being 2.5 for =20-year latency.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Exposition professionnelle, Carcinogène, Poussière, Silice, Homme, Toxicité, Epidémiologie, Mortalité, Morbidité, In vitro, Leucocyte, Finlande, Europe, Granite, Médecine travail, Poumon pathologie, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Occupational exposure, Carcinogen, Dust, Silica, Human, Toxicity, Epidemiology, Mortality, Morbidity, In vitro, Leukocyte, Finland, Europe, Granite, Occupational medicine, Lung disease, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0050780
Code Inist : 002B11A. Création : 09/06/1995.