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  1. Bendectin and birth defects. I : A meta-analysis of the epidemiologic studies.

    Article - En anglais

    « Bendectin » 1 (Doxylamine/Dicyclomine/Pyridoxine) was widely used for the treatment of nausea and vomiting of pregnancy until 1983, when production was discontinued in the face of lawsuits alleging that the drug caused congenital malformations.

    We have conducted a meta-analysis of the 16 cohort and 11 case-control studies that report birth defects from Bendectin-exposed pregnancies.

    This meta-analysis provides an estimate of the relative risk of malformation at birth in association with Bendectin exposure.

    The pooled estimate of the relative risk of any malformation at birth in association with exposure to Bendectin in the first trimester was 0.95 (95% CI 0.88 to 1.04).

    Mots-clés Pascal : Doxylamine, Dicyclovérine, Pyridoxine, Association médicamenteuse, Antiémétique, Toxicité, Tératogène, Malformation, Homme, Gestation, Epidémiologie, Métaanalyse, Prévalence, Article synthèse, Etats Unis, Amérique du Nord, Amérique, Antihistaminique, Récepteur histaminergique H1, Spasmolytique, Vitamine

    Mots-clés Pascal anglais : Pyridoxine, Drug combination, Antiemetic, Toxicity, Teratogen, Malformation, Human, Pregnancy, Epidemiology, Metaanalysis, Prevalence, Review, United States, North America, America, Antihistaminic, H1 receptor, Antispasmodic agent, Vitamin

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0029530

    Code Inist : 002B02H. Création : 09/06/1995.