Safety and cost-effectiveness of solvent-detergent-treated plasma : in search of a zero-risk blood supply.
- To determine the public health and economic implications of solvent-detergent-treated frozen plasma (SD FP).
While this processing technique nearly eliminates the risk of transmitting lipid-enveloped viruses (hepatitis B and C and human immunodeficiency virus), it has associated costs and, because it requires pooling many plasma units, may increase risks of nonenveloped virus transmission.
- A previously published Markov decision analysis model was modified to assess transfusion-related outcomes in hypothetical cohorts of plasma recipients.
In-hospital mortality and other characteristics were determined in 61 patients receiving plasma transfusions at a medium-sized tertiary care center to provide data for the model.
Other parameters were obtained from the medical literature.
Mots-clés Pascal : Coût, Efficacité, Test sécurité, Plasma sanguin, Transmission, SIDA, Virose, Infection, Hépatite virale B, Hépatite virale, Homme, Hémopathie, Maladie sexuellement transmissible, Immunopathologie, Foie pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Costs, Efficiency, Safety test, Blood plasma, Transmission, AIDS, Viral disease, Infection, Viral hepatitis B, Viral hepatitis, Human, Hemopathy, Sexually transmitted disease, Immunopathology, Hepatic disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0022064
Code Inist : 002B06D01. Création : 09/06/1995.