It was the objective of this study to document and evaluate AZT-induced short-term toxicity in healthy individuals.
The study was designed as a longitudinal monocentric side-effect monitoring study with prospective data collection.
It was carried out at the Cologne University Hospital.
The study population comprised health care workers who were taking AZT prophylaxis after accidental exposure to HIV-infected blood.
Fourteen individuals were included into the study ; seven of them discontinued treatment prematurely, five due to severe subjective symptoms.
In case of one worker AZT had to be stopped due to severe neutropenia (800 cells/mul) with signs of upper respiratory tract infection.
Mots-clés Pascal : SIDA, Virose, Infection, Sang, Contamination, Exposition professionnelle, Agent santé, Zidovudine, Antiviral, Pyrimidine nucléoside, Toxicité, Complication, Prévention, Homme, Immunopathologie, Immunodéficit, Médecine travail, Chimioprophylaxie
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Blood, Contamination, Occupational exposure, Health worker, Antiviral, Pyrimidine nucleoside, Toxicity, Complication, Prevention, Human, Immunopathology, Immune deficiency, Occupational medicine, Chemoprophylaxis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0015395
Code Inist : 002B06D01. Création : 09/06/1995.