The Edinburgh Randomised Trial of Breast Cancer Screening recruited 44,288 women aged 45-64 years into the initial cohort of the trial during 1978-81, and 10 years of follow-up is now complete.
A total of 22,944 women were randomised into the study group and were offered screening for 7 years ; the remaining women formed the control group.
After 10 years, breast cancer mortality is 14-21% lower in the study group than in the controls depending on the precise definition of the end point.
These differences are not statistically significant ; for breast cancer as the underlying cause of death the relative risk is 0.82 (95% confidence interval 0.61-1.11).
Rates of locally advanced and metastatic cancer were substantially lower in the study group, but screening has failed to achieve marked reductions in rates of small node-positive cancers.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Dépistage, Mortalité, Etude longitudinale, Epidémiologie, Ecosse, Grande Bretagne, Royaume Uni, Europe, Homme, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Medical screening, Mortality, Follow up study, Epidemiology, Scotland, Great Britain, United Kingdom, Europe, Human, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0011555
Code Inist : 002B20E02. Création : 09/06/1995.