This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes.
The study included Maryland basal cell carcinoma patients and cancer-free dermatologic controls who had had noncancerous skin disorders diagnosed between 1987 and 1990.
Logistic regression models were used to assess the independent effect of the selected variables stratified by DNA repair level, with adjustment for age and family history.
Skin type, lifetime number of severe sunburns, and actinic elastosis were also selected as risk factors for basal cell carcinoma.
Cryopreserved lymphocytes from 88 cases and 135 controls were used for the DNA repair assay.
Mots-clés Pascal : Epidémiologie moléculaire, Epithélioma basocellulaire, Peau, DNA, Réparation, Soleil, Marqueur biologique, Homme, Peau pathologie, Tumeur maligne, Acide nucléique
Mots-clés Pascal anglais : Molecular epidemiology, Basal cell carcinoma, Skin, DNA, Repair, Sun, Biological marker, Human, Skin disease, Malignant tumor, Nucleic acid
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0008569
Code Inist : 002B08A. Création : 09/06/1995.