Progestogen use and decreased risk of breast cancer in a cohort study of premenopausal women with benign breast disease.
A cohort study of 1,150 premenopausal French women with benign breast disease diagnosed in two breast clinics between 1976 and 1979 was carried out to analyse the relationship between progestogen use and the risk of breast cancer.
The follow-up accumulated 12,462 person-years.
The risk of breast cancer was estimated using a Poisson regression analysis on person-time data and the proportional hazards model.
In the latter analysis, cumulated progestogen use and age were considered as time-varying covariables and adjustment was performed on the main risk factors for breast cancer.
Neither overall progestogen use nor the duration of use was found to be significantly associated with the risk of breast cancer.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Mastopathie bénigne, Prévention, Etude cohorte, Progestatif, Epidémiologie, Homme, Glande mammaire pathologie, Hormone stéroïde sexuelle, Hormone ovarienne, Chimioprophylaxie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Benign mastopathy, Prevention, Cohort study, Progestagen, Epidemiology, Human, Mammary gland diseases, Sex steroid hormone, Ovarian hormone, Chemoprophylaxis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0002082
Code Inist : 002B20E02. Création : 09/06/1995.