Postlicensure effectiveness of the Haemophilus influenzae type b polysaccharide-Neisseria meningitis outer-membrane protein complex conjugate vaccine among Navajo children.
The incidence of invasive Haemophilus influenzae type b (Hib) infection has decreased significantly among Navajo children since the licensure of Hib conjugate vaccines, even though two lots of Hib (polyribosylribitol phosphate) - meningococcal B outer-membrane protein conjugate vaccine (PRP-OMP) widely used among the Navajo were later found to be of low immunogenicity.
We measured the effectiveness of all Hib conjugate vaccines combined, PRP-OMP alone, and the PRP-OMP lots with lower-than-expected immunogenicity among Navajo infants and children.
This was a matched case-control study using active, laboratory-based surveillance for the ascertainment of Navajo children 2 1/2 to 59 months of age with invasive Hib infection ; 45 patients with infection and 180 control subjects were enrolled.
Mots-clés Pascal : Enfant, Homme, Ethnie, Amérindien, Etats Unis, Amérique du Nord, Amérique, Vaccination, Vaccin associé, Haemophilus influenzae, Pasteurellaceae, Bactérie, Neisseria meningitidis, Neisseriaceae, Micrococcales, Efficacité traitement, Immunisation passive, Evaluation, Prévention
Mots-clés Pascal anglais : Child, Human, Ethnic group, Amerindian, United States, North America, America, Vaccination, Mixed vaccine, Haemophilus influenzae, Pasteurellaceae, Bacteria, Neisseria meningitidis, Neisseriaceae, Micrococcales, Treatment efficiency, Passive immunization, Evaluation, Prevention
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0715574
Code Inist : 002B05A02. Création : 09/06/1995.