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  1. Postlicensure effectiveness of the Haemophilus influenzae type b polysaccharide-Neisseria meningitis outer-membrane protein complex conjugate vaccine among Navajo children.

    Article - En anglais

    The incidence of invasive Haemophilus influenzae type b (Hib) infection has decreased significantly among Navajo children since the licensure of Hib conjugate vaccines, even though two lots of Hib (polyribosylribitol phosphate) - meningococcal B outer-membrane protein conjugate vaccine (PRP-OMP) widely used among the Navajo were later found to be of low immunogenicity.

    We measured the effectiveness of all Hib conjugate vaccines combined, PRP-OMP alone, and the PRP-OMP lots with lower-than-expected immunogenicity among Navajo infants and children.

    This was a matched case-control study using active, laboratory-based surveillance for the ascertainment of Navajo children 2 1/2 to 59 months of age with invasive Hib infection ; 45 patients with infection and 180 control subjects were enrolled.

    Mots-clés Pascal : Enfant, Homme, Ethnie, Amérindien, Etats Unis, Amérique du Nord, Amérique, Vaccination, Vaccin associé, Haemophilus influenzae, Pasteurellaceae, Bactérie, Neisseria meningitidis, Neisseriaceae, Micrococcales, Efficacité traitement, Immunisation passive, Evaluation, Prévention

    Mots-clés Pascal anglais : Child, Human, Ethnic group, Amerindian, United States, North America, America, Vaccination, Mixed vaccine, Haemophilus influenzae, Pasteurellaceae, Bacteria, Neisseria meningitidis, Neisseriaceae, Micrococcales, Treatment efficiency, Passive immunization, Evaluation, Prevention

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0715574

    Code Inist : 002B05A02. Création : 09/06/1995.