Screening for hemochromatosis : a cost-effectiveness study based on 12,258 patients.
Current emphasis in hemochromatosis has focused on early detection and treatment to prevent permanent liver damage and hepatocellular carcinoma.
Thus far, only normal population and highrisk groups have been screened but not patients seeking medical care.
Serum iron levels were determined in consecutive fasting blood samples collected in the morning from 12,258 Mayo Clinic patients.
One hundred twenty-seven patients had an initial serum iron concentration =180 mug/dL.
Eight patients (age, 38-71 years ; 7 men and 1 woman) had transferrin saturation =62% (range, 84-99) and serum ferritin value =400 mug/L (range, 457-4004) with no other explanation for the abnormal iron test results.
Mots-clés Pascal : Hémochromatose, Economie, Coût, Epidémiologie, Homme, Homozygotie, Hétérozygotie, Prévention, Complication, Pigment, Fer, Analyse quantitative, Plasma sanguin, Métabolisme pathologie, Enzymopathie
Mots-clés Pascal anglais : Hemochromatosis, Economy, Costs, Epidemiology, Human, Homozygozity, Heterozygozity, Prevention, Complication, Pigments, Iron, Quantitative analysis, Blood plasma, Metabolic diseases, Enzymopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0714708
Code Inist : 002B30A03B. Création : 09/06/1995.