Infection is a frequent cause of morbidity and mortality at the extremes of life.
Its treatment is complicated by a lack of specificity in the clinical findings and wider range of pathogens than in other patients.
For these reasons empirical therapy must cover a wide range of pathogens and yet, because the clinical findings may not even be due to infection, it should be as non-toxic as possible.
It is also essential to investigate intensely before therapy so as to stand the best chance of making an aetiological diagnosis and possibly allowing a change to more directed therapy.
Neonates in particular, but also the elderly, are susceptible to age-associated antibiotic toxicities, such as those from tetracyclines and chloramphenicol.
Mots-clés Pascal : Antibiotique, Antibactérien, Choix, Contrainte, Article synthèse, Epidémiologie, Nouveau né, Homme, Vieillard
Mots-clés Pascal anglais : Antibiotic, Antibacterial agent, Choice, Constraint, Review, Epidemiology, Newborn, Human, Elderly
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0683693
Code Inist : 002B02S02. Création : 09/06/1995.