Infection determinants at extremes of age.
The immune defence of the full-term neonate is compromised in several ways.
Although adequate numbers of B lymphocytes are present, antibody production may be delayed compared with the adult.
Decreased levels of complement components contribute to the impaired opsonization potential of newborn sera and in turn, to impaired chemotactic responses of neonatal polymorphonuclear leucocytes (PMN).
Multiple abnormalities in neonatal PMN function, coupled with deficient bone marrow supplies during stress, contribute greatly to the increased vulnerability to infection of neonates.
Infection is a major problem for infants born before 28 weeks.
Their serum IgG antibody levels are extremely low and the deficiencies in complement levels and PMN chemotatic responses noted in full-term neonates are even more marked and persist for longer.
Mots-clés Pascal : Infection, Facteur risque, Article synthèse, Réponse immune, Immunodéficit, Immunité cellulaire, Foetus, Nouveau né, Homme, Nourrisson, Epidémiologie
Mots-clés Pascal anglais : Infection, Risk factor, Review, Immune response, Immune deficiency, Cellular immunity, Fetus, Newborn, Human, Infant, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0683692
Code Inist : 002B05A03. Création : 09/06/1995.