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  1. The effects of intrathecal morphine and clonidine on the prevention and reversal of spinal cord hyperxcitability following sciatic nerve section in the rat.

    Article - En anglais

    We have previously shown that intrathecal (i.t.) morphine, but not the alpha2-adrenoreceptor agonist clonidine, administered prior to sciatic nerve section, reduced the level of autotomy in rats, which is a behavioural model of neuropathic pain.

    Neither drug was effective when administered 15 min after nerve section.

    We now examined the effects of i.t. morphine and clonidine on the development of flexor reflex hyperexcitability following sciatic nerve section in acute physiological experiments.

    The flexor reflex was recorded from the hamstring muscles in decerebrate, spinalized, unanesthetized rats.

    Mots-clés Pascal : Cou, Douleur, Système ostéoarticulaire pathologie, Homme, Travail, Médecine travail, Perception sensorielle, Exposition professionnelle, Personnalité, Psychologie, Névrotisme, Cervicalgie

    Mots-clés Pascal anglais : Neck, Pain, Diseases of the osteoarticular system, Human, Labour, Occupational medicine, Sensorial perception, Occupational exposure, Personality, Psychology, Neuroticism

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0682205

    Code Inist : 002B15I. Création : 09/06/1995.