Early indicators of renal dysfunction in silicotic workers.
The aim of the study was to determine whether silicosis is associated with renal alterations detectable in urinary or blood-borne indicators of nephrotoxicity.
The study used a cross-sectional design.
The subjects comprised 116 male workers who had been exposed to silica for at least two years and had been diagnosed as having silicosis and 61 age-matched referents.
The considered outcome measures were the concentrations of beta - microglobulin and creatinine in serum and the urinary excretion of albumin, retinol-binding protein, and beta-N-acetyl-D-glucosaminidase.
Compared with the referents, the silicotic subjects excreted, on the average, slightly higher amounts of albumin, retinol-binding protein, and beta-N-acetyl-D-glucosaminidase.
Mots-clés Pascal : Silicose, Silice, Exposition professionnelle, Rein pathologie, Toxicité, Albumine, Enzyme, Protéinurie, Homme, Médecine travail, Appareil respiratoire pathologie, Poumon pathologie, Pneumoconiose, Maladie professionnelle, Appareil urinaire pathologie
Mots-clés Pascal anglais : Silicosis, Silica, Occupational exposure, Renal disease, Toxicity, Albumin, Enzyme, Proteinuria, Human, Occupational medicine, Respiratory disease, Lung disease, Pneumoconiosis, Occupational disease, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0680177
Code Inist : 002B03L03. Création : 09/06/1995.