The characteristics of lung cancers induced by inhaled chromate were studied in 13 consecutive autopsies on male ex-chromate workers.
In addition to histopathology, we examined : (1) the relationship between the occurrence of lung cancer and the amount of chromium (Cr) deposited in the lung as determined by atomic absorptiometry and (2) the chronological changes in five precancerous lung lesions followed by bronchoscopy till death.
Twenty-one cancers were identified, including 16 lung tumours observed either during follow-up or at autopsy.
Of these 16 tumours, 13 were found in six subjects, implying a high frequency of multiple cancers.
Eleven (69%) out of the 16 tumours were of squamous cell type (including carcinoma in situ), this being twice as frequent as in age-matched controls.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Lésion précancéreuse, Exposition professionnelle, Composé chimique, Chromate, Chrome, Dépôt, Toxicité, Etiologie, Autopsie, Homme, Poumon pathologie, Bronche pathologie, Appareil respiratoire pathologie, Médecine travail, Médecine légale
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Premalignant lesion, Occupational exposure, Chemical compound, Chromates, Chromium, Deposition, Toxicity, Etiology, Autopsy, Human, Lung disease, Bronchus disease, Respiratory disease, Occupational medicine, Legal medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0662393
Code Inist : 002B11A. Création : 09/06/1995.