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  1. Mortality during initial and during later lithium treatment : a collaborative study by the International Group for the Study of lithium-treated patients.

    Article - En anglais

    We have previously shown that the mortality of patients with recurrent affective disorders in long-term lithium treatment is not higher than that of the general population.

    In the present study on 471 patients from Denmark and Germany, we examined mortality during the initial year of lithium treatment and during later lithium treatment.

    During initial lithium treatment, the total mortality was twice as high as in the general population (difference not significant) and the mortality due to suicide 16 times higher.

    During later lithium treatment, the mortality rates did not differ from those in the general population.

    Our results indicate that patients with frequent, often severe recurrences, those chosen for prophylactic lithium treatment, are at risk of high mortality, which then diminishes as the prophylactic action of the treatment takes effect.

    Mots-clés Pascal : Trouble humeur, Prévention, Récidive, Etude longitudinale, Chimiothérapie, Traitement, Lithium, Psychotrope, Mortalité, Facteur risque, Suicide, Homme, Epidémiologie

    Mots-clés Pascal anglais : Mood disorder, Prevention, Relapse, Follow up study, Chemotherapy, Treatment, Lithium, Psychotropic, Mortality, Risk factor, Suicide, Human, Epidemiology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0657595

    Code Inist : 002B02B02. Création : 09/06/1995.