Hepatitis C virus genotype 4 is highly prevalent in central Africa (Gabon).

Hepatitis C virus genotype 4 is highly prevalent in central Africa (Gabon).

Réf. 94390 Article - En anglais

JOURNAL OF GENERAL VIROLOGY, vol. 75, p.9, 1994, pages 2393-2398, réf. 1p., ISSN 0022-1317, GBR

LI-ZHE (X.U.), LARZUL (D.) ^*, DELAPORTE (E.) ^*, BRECHOT (C.), KREMSDORF (D.)

Inst Pasteur. Hybridotest. Paris. FRA

Following a survey of hepatitis C virus (HCV) infection recently carried in central Africa (Gabon), we cloned and sequenced PCR products of the 5'non-coding and capsid-encoding regions of HCV RNA from three randomly selected HCV RNA-positive Gabonese subjects.
In the capsid-encoding region, the identity between the three Gabonese isolates was 91 to 98%. The three Gabonese sequences showed a divergence of 11 to 17% from published HCV genotypes I to IV (1a, 1b, 2a and 2b) isolates and of 6 to 11% from HCV genotype 4 isolates.
Thus the Gabonese isolates, termed HC-G, belong to HCV genotype 4.

Mots-clés BDSP : Virus, Prévalence, Gabon, Afrique, Homme, Epidémiologie, Virose, Infection, Appareil digestif [pathologie], Foie [pathologie]

Mots-clés Pascal : Virus hépatite C, Flaviviridae, Virus, Prévalence, Gabon, Afrique, Homme, Epidémiologie, Hépatite virale C, Virose, Infection, Appareil digestif pathologie, Foie pathologie

Mots-clés Pascal anglais : Hepatitis C virus, Flaviviridae, Virus, Prevalence, Gabon, Africa, Human, Epidemiology, Viral hepatitis C, Viral disease, Infection, Digestive diseases, Hepatic disease

Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique

Cote : 94-0657158
Code Inist : 002B05C02G. Création : 09/06/1995.

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