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  1. Hepatitis C virus genotype 4 is highly prevalent in central Africa (Gabon).

    Article - En anglais

    Following a survey of hepatitis C virus (HCV) infection recently carried in central Africa (Gabon), we cloned and sequenced PCR products of the 5'non-coding and capsid-encoding regions of HCV RNA from three randomly selected HCV RNA-positive Gabonese subjects.

    In the capsid-encoding region, the identity between the three Gabonese isolates was 91 to 98%. The three Gabonese sequences showed a divergence of 11 to 17% from published HCV genotypes I to IV (1a, 1b, 2a and 2b) isolates and of 6 to 11% from HCV genotype 4 isolates.

    Thus the Gabonese isolates, termed HC-G, belong to HCV genotype 4.

    Mots-clés Pascal : Virus hépatite C, Flaviviridae, Virus, Prévalence, Gabon, Afrique, Homme, Epidémiologie, Hépatite virale C, Virose, Infection, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Hepatitis C virus, Flaviviridae, Virus, Prevalence, Gabon, Africa, Human, Epidemiology, Viral hepatitis C, Viral disease, Infection, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0657158

    Code Inist : 002B05C02G. Création : 09/06/1995.