Pulmonary function decline and a 17-year total mortality : the Honolulu heart program.
The Honolulu Heart Program continues to follow a cohort of Japanese-American men initially aged 45-68 years, of whom 4,000 had three acceptable measurements of forced expiratory volume in 1 second (FEV1) between 1965 and 1974 and were free of cardiovascular disease and cancer.
The 6-year rate of change (slope) in FEV1 was calculated using a within-person linear regression method.
Men were divided into tertiles based on the rate of change in FEV1.
During 17 subsequent years of follow-up, 796 deaths occurred.
The tertile with the greatest rate of decline in FEV1 (mean, - 61 ml/year) had the highest age-adjusted total mortality rate (17.3/1,000 person-years), followed by rates of 13.2 for the middle tertile (mean, - 25 ml/year) and 11.0 for men with the smallest change in FEV1 (mean, 9 ml/year) (test for trend, p<0.0001).
Mots-clés Pascal : Mortalité, Fonction respiratoire, Japonais, Hawaï, Homme, Etude longitudinale, Epidémiologie, Tabagisme, Appareil respiratoire, Poumon, Polynésie, Océanie
Mots-clés Pascal anglais : Mortality, Lung function, Japanese, Hawaii, Human, Follow up study, Epidemiology, Tobacco smoking, Respiratory system, Lung, Polynesia, Oceania
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0647072
Code Inist : 002B30A01A2. Création : 09/06/1995.