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  1. Validation of the proposed World Health Organization staging system for HIV disease and infection in a cohort of intravenous drug users.

    Article - En anglais

    Objective 

    To assess the prognostic utility of the clinical criteria of the World Health Organization's (WHO) proposed staging system for HIV disease and infection in a cohort of intravenous drug users (IVDU) from the ALIVE study.

    Methods 

    All study subjects known to be HIV-seropositive were included in this analysis.

    Subjects were classified as WHO clinical stage 1,2, or 3 at their initial seropositive evaluation.

    Product-limit estimates and Cox proportional hazard models were used to compare time of progression to AIDS (stage 4) for the first three clinical stages.

    Results 

    Of the original cohort of 2921 IVDU in the ALIVE study, 694 were known to be HIV-positive by january 1992.

    At the time of their index visit, 49% of the cohort were WHO clinical stage 1,10% stage 2 and 41% were stage 3.

    Mots-clés Pascal : SIDA, Virose, Infection, OMS, Evolution, Toxicomanie, Symptomatologie, Stade clinique, Classification par stade, Prédiction, Voie intraveineuse, Homme, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, WHO, Evolution, Drug addiction, Symptomatology, Clinical stage, Staging, Prediction, Intravenous administration, Human, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0645316

    Code Inist : 002B06D01. Création : 09/06/1995.