Transfusion-transmitted human T-cell lymphotropic virus type I infection in Taiwan : a true risk and occasional coinfection with hepatitis C virus shown in a prospective study.
To study the incidence of human T-cell lymphotropic virus (HTLV) after blood tranfusion in Taiwan, serum samples from 699 patients in a prospective study were examined for seroreactivity of anti-HTLV.
By an enzyme immunoassay, 9 of the 699 recipients were repeatedly positive.
Serial serum samples of these 9 patients were then confirmed with a Western blot analysis and with a polymerase chain reaction (PCR) assay for HTLV-1 genome.
Four were already positive for anti-HTLV before tranfusion, 1 carried antibodies to HTLV-I transiently after transfusion, and only 4 cases had de nova seroconversions.
These patients and their family members were called back and tested for HTLV-1 genome in the peripheral blood mononuclear cell (PBMC) and plasma.
Mots-clés Pascal : Virus HTLV1, Retroviridae, Virus, Transmission, Sang, Transfusion, Homme, Taiwan, Asie, Incidence
Mots-clés Pascal anglais : HTLV-I virus, Retroviridae, Virus, Transmission, Blood, Transfusion, Human, Taiwan, Asia, Incidence
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0638421
Code Inist : 002B27D01. Création : 09/06/1995.