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  1. Erythropoietin-independent colonies of red blood cells and leukocytosis in a worker exposed to low levels of benzene.

    Article - En anglais


    Exposure to high levels of benzene commonly results in the suppression of hemopoiesis, although cases of leukocytosis and leukocytosis with thrombocytosis have been reported.

    No hematologic abnormalities have generally been found with exposure to low levels of benzene.

    METHODS A pipe fitter exposed to low levels of benzene (time-weighted average 0.9 ppm) developed leukocytosis.

    His blood counts and growth of erythroid burst forming units (BFU-E) was followed with and without the addition of erythropoietin.


    Erythropoietin-independent BFU-E colonies were increased to 40 per 4x104 cells (normal<3 PER 4x104 cells).

    Both the leukocyte count and the number of erythropoietin-independent BFU-E colonies decreased when exposure to benzene was terminated.

    Mots-clés Pascal : Leucocytose, Exposition professionnelle, Toxicité, Solvant organique, Dose faible, Benzène, Homme, Hématopoïèse, Cellule érythroïde, Unité formatrice colonie, Médecine travail

    Mots-clés Pascal anglais : Leukocytosis, Occupational exposure, Toxicity, Organic solvent, Low dose, Benzene, Human, Hematopoiesis, Erythroid cell, Colony forming cell, Occupational medicine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0636555

    Code Inist : 002B03L04. Création : 09/06/1995.