The joint effects of exposure to two known lung carcinogens, tobacco smoking and asbestos, are reviewed.
The variable pattern of interaction - ranging from supramultiplicative to less than additive - may reflect the fact that both asbestos and smoking are complex carcinogens which can affect more than one stage of lung carcinogenesis.
The joint effect of two such agents will depend on the relative magnitude of the effects at each stage.
The epidemiologic evidence from studies of insulation workers with high exposures suggests an interaction that approximates the multiplicative model, indicating that each of the two factors has an independent action on the multistage process of carcinogenesis.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Epidémiologie, Carcinogène, Amiante, Fibre minérale, Exposition professionnelle, Toxicité, Interaction toxique, Tabagisme, Homme, Article synthèse, Médecine travail, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Epidemiology, Carcinogen, Asbestos, Mineral fiber, Occupational exposure, Toxicity, Poison interaction, Tobacco smoking, Human, Review, Occupational medicine, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0634785
Code Inist : 002B11A. Création : 09/06/1995.