The authors studied the effects of routine varicella immunization of US preschool children and of implementation of a catch-up program in older children on the age distribution of cases and on overall morbidity, with emphasis on the sensitivity of the results to level of vaccine coverage, duration of protection, responsiveness to boosting, relative residual susceptibility and infectiousness, and degree of morbidity among vaccine breakthrough cases.
An age-structured theoretical transmission model was used, with values for vaccine efficacy based on a review of the literature by an expert panel.
Mots-clés Pascal : Varicelle, Virose, Infection, Vaccination, Prévention, Enfant, Homme, Age préscolaire, Modèle mathématique, Efficacité, Evaluation, Epidémiologie, Morbidité, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Varicella, Viral disease, Infection, Vaccination, Prevention, Child, Human, Preschool age, Mathematical model, Efficiency, Evaluation, Epidemiology, Morbidity, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0622889
Code Inist : 002B05C02B. Création : 09/06/1995.