Genotoxic risk for humans due to work place exposure to ethylene oxide : remarkable individual differences in susceptibility.
Single strand breaks of DNA of peripheral mononuclear blood cells from 97 male and female workers occupationally exposed to ethylene oxide were analysed by the alkaline elution method.
These individuals were occupied with the sterilization of medical devices in hospitals and in commercial plants.
Ethylene oxide in the air of the working areas was detected up to a maximal concentration of 16.5 mg/m3 calculated as 4-h time-weighted average (4h TWA).
Mean value was 1.47±0.52 mg/m3 (1 mg/m3=0.55 ppm).
Mots-clés Pascal : Oxirane, Toxicité, DNA, Homme, Exposition professionnelle, Médecine travail, Comparaison interindividuelle, Sensibilité résistance, Stérilisation chimique, Cassure monocaténaire, Mutagène, Carcinogène
Mots-clés Pascal anglais : Ethylene oxide, Toxicity, DNA, Human, Occupational exposure, Occupational medicine, Interindividual comparison, Sensitivity resistance, Chemical sterilization, Single strand break, Mutagen, Carcinogen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0620853
Code Inist : 002B03L02. Création : 09/06/1995.