Six foundrymen occupationally exposed to cadmium fumes excreted in random urine samples 4.8±2.9 mug cadmium/g creatinine (±S.D.). Six controls excreted 0.15±0.09 mug/kg creatinine (±S.D.). The excretion of glycosaminogly cans by exposed men (2.3±1.1 mg/mmol creatinine, ±S.D.) did not differ from that of controls (2.3±1.6 mg/mmol, ±S.D.). However, electrophoretic analysis of the isolated urinary proteogly can fraction revealed a dose-dependent progressive increase in the intensity of two bands with a molecular weight between 45,000 and 50,000.
In control urines and in samples with urinary cadmium less than 3 mug/g creatinine, only one major band with a molecular weight of 100,000 was detected.
Mots-clés Pascal : Cadmium, Exposition professionnelle, Médecine travail, Appareil urinaire pathologie, Rein pathologie, Rein, Homme, Marqueur biologique, Urine, Protéoglycane, Métal lourd, Toxicité
Mots-clés Pascal anglais : Cadmium, Occupational exposure, Occupational medicine, Urinary system disease, Renal disease, Kidney, Human, Biological marker, Urine, Proteoglycan, Heavy metal, Toxicity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0602013
Code Inist : 002B03L05. Création : 09/06/1995.