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Increased incidence of HLA antigen B35 in patients with chronic lymphocytic leukemia.
LEUKEMIA RESEARCH, vol. 18, n° 8, 1994, pages 565-567, 16 réf., ISSN 0145-2126, GBR
CUTTNER (J.), SKERRETT (D.), ROSINA (O.), TROY (K.M.), WALLENSTEIN (S.), SPIVACK (M.)
Mount Sinai medical cent. Dep biostatistics. Div hematology. New York NY. USA
We and others have reported an increased incidence of chronic lymphocytic leukemia (CLL) among Ashkenazi (ASH) Jews of European origin.
We performed HLA Class I typing on all 50 CLL patients seen by us and compared them with 3886 controls consisting of healthy blood donors from the New York Blood Center.
Thirty of our CLL patients were ASH Jews, 17 of whom (57%) expressed the B35 antigen compared with 462 ASH controls (26%). Seven (39%) of the CLL Caucasian patients expressed the B35 antigen compared with 305 (14.5%) of the Caucasian controls.
Combining the information from the ASH Jews and the Caucasians the difference is highly significant, (p=0.0001).
The summary odds ratio was 3.7.
Mots-clés BDSP : Incidence, Epidémiologie, Ethnie, Race, Etats Unis, Amérique, Homme
Mots-clés Pascal : Leucémie lymphoïde, Antigène histocompatibilité classe I, Système histocompatibilité majeur, Système HLA, Incidence, Epidémiologie, Juif, Ethnie, Caucasoïde, Race, Etats Unis, Amérique du Nord, Amérique, Homme, Chronique, Hémopathie maligne, Lymphoprolifératif syndrome, Antigène B35
Mots-clés Pascal anglais : Chronic lymphocytic leukemia, Class I histocompatibility antigen, Major histocompatibility system, HLA-System, Incidence, Epidemiology, Jew, Ethnic group, Caucasoid, Race, United States, North America, America, Human, Chronic, Malignant hemopathy, Lymphoproliferative syndrome
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Inist-CNRS - Institut de l'Information Scientifique et TechniqueCote : 94-0593683
Code Inist : 002B19B. Création : 09/06/1995.
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