logo BDSP

Base documentaire

  1. DNA repair capacity as a risk factor for non-melanocytic skin cancer : a molecular epidemiological study.

    Article - En anglais

    Capacity to repair UV-induced DNA damage was studied by use of a host cell reactivation assay in T lymphocytes isolated from 86 cases and 87 controls (aged 44-68 years) who were participants in a population-based case-control study of basal cell (BCC) or squamous cell (SCC) carcinoma of the skin in Geraldton, Western Australia.

    Lymphocytes were cultured and transfected with either control or UV-irradiated plasmids (254 nm, 350 J/m2 containing a reporter gene [the chloramphenicolacetyltransferase (CAT) gene], and the repair capacity was determined by measuring GAT gene expression in protein extracts prepared from the transfected cells.

    Mots-clés Pascal : Epithélioma spinocellulaire, Peau, Epithélioma basocellulaire, Facteur risque, Rayonnement UV, Rayonnement solaire, DNA, Lésion, Réparation, Epidémiologie moléculaire, Carcinogenèse, Australie, Océanie, Ouest, Homme, Tumeur maligne, Peau pathologie, Etude cas témoin

    Mots-clés Pascal anglais : Squamous cell carcinoma, Skin, Basal cell carcinoma, Risk factor, Ultraviolet radiation, Solar radiation, DNA, Lesion, Repair, Molecular epidemiology, Carcinogenesis, Australia, Oceania, West, Human, Malignant tumor, Skin disease, Case control study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0591786

    Code Inist : 002B08A. Création : 09/06/1995.