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  1. Environmental contamination and assessment of exposure to antineoplastic agents by determination of cyclophosphamide in urine of exposed pharmacy technicians : is skin absorption an important exposure route ?

    Article - En anglais

    In the Netherlands, special guidelines and safety precautions were introduced about 10 y ago for preparation and administration of antineoplastic agents.

    However, little is known about the effectiveness of these measures.

    In this study, occupational exposure to antineoplastic agents of nine pharmacy technicians who were involved in drug preparation was investigated.

    Cyclophosphamide, 5-fluorouracil, and methotrexate accounted for 95% of the antineoplastic agents prepared ; therefore, the presence of these compounds was monitored.

    Mots-clés Pascal : Anticancéreux, Pharmacien, Personnel sanitaire, Exposition professionnelle, Cyclophosphamide, Surveillance biologique, Homme, Médecine travail, Absorption, Peau, Voie externe, Pénétration, Prévention, Vêtement protection, Gant

    Mots-clés Pascal anglais : Antineoplastic agent, Chemist, Health staff, Occupational exposure, Biological monitoring, Human, Occupational medicine, Absorption, Skin, Topical administration, Penetration, Prevention, Safety clothing, Glove

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0590372

    Code Inist : 002B02U10. Création : 09/06/1995.