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  1. John Hageman's factor and deep-vein thrombosis : Leiden thrombophilia study.

    Article - En anglais

    Because the relationship between factor XII deficiency and venous thrombosis is unclear and study results seem contradictory, we undertook a population-based case-control study.

    Among 350 unselected patients younger than 70 years, with a first, objectively confirmed, episode of deep-vein thrombosis and without underlying malignant disease we detected a 6% frequency (21/350 patients) of factor XII deficiency (activity level<57%). Among 3 50 healthy control subjects, matched for age and sex, the frequency was 5% (18 subjects).

    Thus there is no increase in prevalence of factor XII deficiency among thrombosis patients and no increase in thrombosis risk for subjects with low factor XII levels (matched odds ratio 1.2 (95% CI 0.6-2.4)).

    Mots-clés Pascal : Thrombose profonde, Veine, Facteur risque, Déficit, Facteur Hageman, Epidémiologie, Pays Bas, Europe, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie, Coagulopathie, Hémopathie, Etude cas témoin

    Mots-clés Pascal anglais : Deep vein thrombosis, Vein, Risk factor, Deficiency, Factor XII, Epidemiology, Netherlands, Europe, Human, Cardiovascular disease, Vascular disease, Venous disease, Coagulopathy, Hemopathy, Case control study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0581197

    Code Inist : 002B12B03. Création : 09/06/1995.