Norwalk virus (NV) and Norwalk-like viruses are important causes of epidemic nonbacterial gastroenteritis in older children and adults.
Serologic responses to NV of 154 Finnish infants and young children participating in a rotavirus vaccine study were examined by ELISA with a recently available baculovirus-expressed recombinant NV capsid protein.
In 4 serially collected sera (at the median ages of 3,4,14, and 23 months), 49% of children had at least one NV infection over the ~2-year study period.
Children with low NV-specific IgG titers (<1 : 50) at the median age of 4 or 14 months were significantly more likely to acquire an NV infection by the median age of 14 or 23 months, respectively, than children who had higher NV IgG titers (>1 : 50) (P<. 05).
Mots-clés Pascal : Gastroentérite, Virose, Infection, Virus Norwalk, Parvovirus, Parvoviridae, Virus, Prévention, Vaccination, Réponse immune, Nourrisson, Homme, Enfant, Immunoprophylaxie, Pronostic, Finlande, Europe, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie
Mots-clés Pascal anglais : Gastroenteritis, Viral disease, Infection, Norwalk virus, Parvovirus, Parvoviridae, Virus, Prevention, Vaccination, Immune response, Infant, Human, Child, Immunoprophylaxis, Prognosis, Finland, Europe, Digestive diseases, Gastric disease, Intestinal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0581152
Code Inist : 002B05C02F. Création : 09/06/1995.