To evaluate the incidence of human immunodeficiency virus type 2 infections in an endemic African area, we have studied 134 patients from Northeast Zaire.
Sera were tested For.
HIV-1 and HIV-2 antibodies to asses cross-reactivity or a possible double infection.
Sixty five (48.5%) serum samples were reactive For HIV-1 and six (4.5%) For HIV-2 using specific Western blots.
The enzyme immunoassays used to detect HIV-2 showed cross-reactivity with HIV-1 in 17 samples (16.5%). Tests based upon synthetic peptides corresponding to specific from human immnodeficiency viruses confirm their ability to discriminate antibodies directed against both viruses in 42/47 samples (89.4%) ; in 5/47 (10.6%) this test could not distinguish double infection from cross-reactivity.
Mots-clés Pascal : SIDA, Virose, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Virus HIV2, Epidémiologie, Incidence, Anticorps, Homme, Zaïre, Afrique, Sérum, Exploration immunologique, Réaction croisée, Infection mixte, Facteur risque, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, HIV-2 virus, Epidemiology, Incidence, Antibody, Human, Zaire, Africa, Serum, Immunological investigation, Cross reaction, Mixed infection, Risk factor, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0569727
Code Inist : 002B06D01. Création : 09/06/1995.