A 26-year follow-up study of 8,006 men enrolled in the Honolulu Heart Program examined the effect of cigarette smoking on the risk of developing idiopathic Parkinson's disease.
Cases were identified through an ongoing search of hospital records and by the review of death certificates and medical records of local neurologists.
Men who had smoked cigarettes at any time prior to study enrollment in 1965 had a reduced risk of developing idiopathic Parkinson's disease (relative risk=0.39).
Examination of smoking by pack-years revealed an apparent dose-response effect on the risk of idiopathic Parkinson's disease, but not on the age of onset.
Mots-clés Pascal : Tabagisme, Toxicité, Homme, Parkinson maladie, Epidémiologie, Etude longitudinale, Hawaï, Polynésie, Océanie, Prospective, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative
Mots-clés Pascal anglais : Tobacco smoking, Toxicity, Human, Parkinson disease, Epidemiology, Follow up study, Hawaii, Polynesia, Oceania, Prospective, Nervous system diseases, Central nervous system disease, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0556024
Code Inist : 002B03L03. Création : 09/06/1995.